A○S has essentially no action, nor is it about relationships; nor is it a comedy, though there are moments of dark humor. Instead, it is a psychological portrait of a mentally ill young woman, seen through her own eyes.
The book's protagonist and narrator (who is always drawn naked, but never titillatingly so) is searching for friends, and the book consists of brief episodes from her quest. But she is schizophrenic, and the stories follow the twisted logic of her own mind, without distinguishing between reality, her delusions, and allegory. Though she is desperately lonely, the bizarre behavior that her illness gives rise to dooms her quest to failure: in one episode, for example, she tries to make friends by telling a stranger in a convenience store that the shampoo may be poisoned.
-from Completely Futile