A lot of good ones have already been mentioned, but if you don't mind Science-fiction, take a look at Yome ga Kore na Monde. by MIYATA Kouji. It's a humourous slice of life about a salaryman, his alien wife and their interspecific baby.
There is also a newly scanlated series that looks promising: Chichi Kogusa by TAGAWA Mi. The setting is ancient Japan where a wandering herbalist and workaholic tries awkwardly to raise his son after his wife's death.