Quote from base_coat
Yoite is not male. Unless... Miharu is a girl? XD
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Actually, Yoite is supposed to be a hermaphrodite. He lives as male, looks male, but was born with both male and female organs. He is voiced by a male actor, and referred to as male by himself and others.
Hope that clears things up for you! As far as I'm concerned, Yoite is male and there is a light dusting of shounen-ai in his relationship with Miharu. It was very light, but it was still there. It could be that female authors don't understand how to write male friendships and that any romantic undertones were unintentional.