Quote from silvarion
so, no one mentioned comedy manga yet.
and about childhood main character, it really is rare, isn't it?
The cliché is to separate them and reunite them later (you can try Mahoraba for that cliché, it is a very good comedy manga imho). I suppose I can also mention Haganai, but I'm not a big fan of it, I liked the original idea, but I think it went downhill quite fast.
The only one I can recall that fits your scenario is probably D-Ash. It's not so romance related though.
I can also mention Sakurasou no Pet na Kanojo since I'm an Aoyama fan (there is also another couple which fits that scenario in it), but it's unlikely she's gonna win. There is a novel for it.
And putting childhood friends aside, Molester Man is the only finished romance story I rated with a 9/10 in the last 4-5 years, I think. Comedy is very good, so you should try it, don't let the art stop you.
Also I don't see anything by TAKEMIYA Yuyuko on your lists, you should try something. Toradora! (novel) is pretty good.
What I like in Trivial Pursuit style. Pick your category: