Any suggestions?

Warau Kanoko-sama - and its sequel Koi Dano Ai Dano
Onani Master Kurosawa - not ecchi
Another

________________

Yahari Ore no Seishun Rabukome wa Machigatte Iru

Watashi ga Motenai no wa do Kangaetemo Omaera ga Warui! Main character realizes she has become an antisocial loner incapable of even the simplest human interactions without internal disaster. But that doesn't stop her from continually trying to become popular.

Iris Zero, the male lead follow his rule of "minimal exposure".
Kyou no Kira-kun, the female lead I think do not trust people because she was bullied when she was in middle school..

________________
ABNKKBSNPLAko

Downloaded over 750+ manga and counting.

FROM PH.

you could try Kami nomi zo Shiru Sekai but its really only the very beginning that he is antisocial, after that he gets kinda forced into being social

________________
__________________________

Like educational manga? take a look at Ed U. Manga's list of manga here

I second Yahari.
Also:
Hyouka
NHK ni Youkoso!
Sayonara Zetsubou Sensei

On a weird, kind of serious level, Welcome to NHK! was interesting. Quite relevant due to the rise of hikikomori/NEETs ("Not in Education, Employment, or Training") in Japan.

________________

No Game No Life isnt out yet but it starts in april and should definitely be put on your to do list since the mcs are basically completely defined by those traits lol... well that and insane intelligence and very loose moral values.

________________
Few favs
Comedy:
Kyou kara ore wa!!, Mx0, Angel Densetsu, Skip Beat, Ai Kora, The Devil King is Bored

Romance:
Hana to Akuma, No bra, Shinigami Trilogy, kindan no koi de ikou, Usagi Drop, Threads of Time, Girl Friends

Most under rated:
Kindan no koi de ikou, kyou kara ore wa!.
m0r l83r... maybe >_>

[m]Kagerou Project[/m] the mc started as a shut in

Kuragehime (has both anime and manga) - About a bunch of female NEETs.

Keppeki Shounen Kanzen Soubi
He's not exactly antisocial, but he has a huge OCD problem which gets in the way of his social life.

________________
"'The lives I've taken will be paid for with my own life.' That's one way to look at it...but it doesn't mean they come back once you die. Lives can also be paid for by the sword; by redeeming yet other lives. That is why 'Hitokiri Battousai' is still alive in the Meiji Era."

don't click this link...