I'm looking for an anime/manga where the MC (has to be male) it abandoned/ignored/hated by the carer/parent/s/whole family (preferably the mother) the story line must cover this at one point or more, not just mention it once then brush over it. He has to me to meet the one/people that abandoned him later on in the story or the beginning, I don't mind. This has to be central to the MC's character, so he can often be cold/angry to the one/s that abandoned him. As a result of him being abandoned the MC changes physically or emotionally, this would be nice. I don't particularly mind how the story turns put as long as it shows the MC's feelings towards the one/s that abandoned him, they could make up or get worse, I leave it to your recommendations.

Examples:
Mahouka Koukou no Rettousei (Novel) (Its easier to put the novel since that mangas are split up)
Orange Marmalade
Doubt! (AMANO Sakuya)

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DO NOT RECOMMEND: 4-Koma, Gender Bender, Lolicon, Shounen Ai, Yaoi, Cheating, Netorare or Rape.

@mu2020 thanks for the recommendation, it looks quite interesting.

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DO NOT RECOMMEND: 4-Koma, Gender Bender, Lolicon, Shounen Ai, Yaoi, Cheating, Netorare or Rape.

I don't think its what you are looking for but this is one of the main plotlines of
Hunter x Hunter -the MC is abandoned by his father because his father wanted to be a hunter instead of taking care of him, the story starts out with the MC going to become a hunter to find his father. But a LOT of stuff happens before he actually finds his father.

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Like educational manga? take a look at Ed U. Manga's list of manga here

Baraou no Souretsu
Fruits Basket more parental abandonment than most manga have room for.

Shiawase Kissa 3-choume. Shindou (one of the male leads) was abandoned by his mother when he was young.

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