I'm wondering at the moment if I can have suggestions for manga where the main girl/ woman is career- orientated in some way. At the very least, a girl or woman who has some ambition other than to get married to her boyfriend in the future (although I won't say no if there is romance, just not a character who's head is filled only with a boyfriend). I hope I'm describing that clear enough. Any suggestions from any genre would be great. thanks for suggestions.

REC and UxU fit your description nicely

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Livin just to keep from dyin

Hataraki Man

there are only a few chapters scanlated, but it should meet your expectations

Spicy Pink. She's a mangaka who isn't all that interested in romance....which isn't to say it doesn't come her way. Josei.

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They say it's the thought that counts, but then they tell you, "The road to hell is paved with good intentions......"

Will no one scanlate Takahashi Miyuki?! T_T

I love that manga!!! waiting for the next chapter to come out

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Listen here
Livin just to keep from dyin

skip beat? the main character isn't career orientated at first (in fact, she wants to get married!), but later gains a dream of becoming an actor.

suppli might be one

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Kimi wa petto

Includes romance, but the heroine is cool and professional woman.

Midnight Secretary starts out like that

The girl in Bakuman wants to be a voice actress so she fits the career oriented part but she isn't the lead by any means. Still the manga is awesome imo, so you should check it out

Btw, can anyone tell me how to link series?

[m]manga name[/m]

example:
Bakuman

Starts out yes....continues? Nope. The career part in MS only really influences the huge romance/smut part of it.

I second Hataraki Man and Kimi wa Petto.
I guess maybe...Cinema Empire kinda fits.

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♪MONSTARR~ will eat all your cookies and steal your bishies~♪ Φ_Φ

Second this. It's a great series