Li began his career in the comics industry in 1982. He self-published Tong Men Shao Nian, a prominent title which rocketed him to fame in 1987. He has since developed a distinctive art style, creating his own visual world with eerily experimental works that broke genre rules. Li’s transmedia creations transcend the boundary of comics and expand into movies, experimental theatres, literature, pop music and sculptures. Recently, the poster that he created for Hong Kong local sci-fi action movie Warriors of Future has been widely praised. He also works with multiple international brands to produce commercial illustrations.

Li is also well-known to the international comics scene. His comics has been serialised and published in places like Japan, Taiwan, Malaysia, Mainland China, France, and Italy since the 1990s.

In 2016, the Hong Kong Arts Centre had jointly curated Li’s solo exhibition, entitled ‘LI Chi-tak, Hong Kong Wizard’, with the Angoulême International Comics Festival in France as one of the Festival’s thematic exhibitions. He was the first Hong Kong comics artist participating in this prestigious festival. This solo exhibition had given birth to another international cooperation opportunity. Li was the first Hong Kong artist being invited to take part in the BD Louvre project, alongside with publishing the comic book titled Moon of the Moon in French and Chinese version.

His recent publications include romance comics Yum Sui, comics that pay homage to Franz Kafka's literary classics Kafka, children comics A Little Strawberry Vol. 1 (Reprint Edition), In the Path Artworks Collection Book by Chi-tak LI, etc.

In 2022, Hong Kong Arts Centre awarded Honorary Fellowships to Li, recognising Li’s invaluable contribution to the arts sector in Hong Kong and Asian region.