Predominantly known for acrylic visual art, Kaneyoa Sachiko is known for imagery that combines the erotic and the grotesque. Common themes include young men, blood, drug use, cartoon animals, uniforms, restraints, and technological body horror.

She describes "the Absolute Territory of the onii-san" as a significant philosophy of her work. Contrasting with the conventional use of "Absolute Territory" to refer to the bare skin between a young woman's socks and skirt, the Abolute Territory of the onii-san conveys masculine eroticism through "for instance...the space between the rolled-up shirtsleeve of a salaryman and his wristwatch...Perhaps the flash of ankle that shows when a man seated on the train or something casually crosses his legs and the cuff of his slacks rides up above his socks" (The Art of Kaneoya Sachiko, Iron Circus Comics, 2018).