Tayutama Kiss on my Deity centers on Yuuri Mito, a student at the Sousei Academy and the only son of the man who runs the Yachimata shrine. At Yachimata, there is a legend of a deity named Tayutayu-sama who protected the area, but this deity and other so-called “Tayutai” have been lost in time.
Mito and his friends discover a relic on the school grounds with mysterious patterns on them. Then, at the opening ceremony of the new school year, an equally mysterious girl named Mashiro appears before Mito. Mashiro is somehow tied to the relic and the legend of Tayutayu-sama.