Makeinu no Nandemoya is definitely a rare gem in the cliche, plotless world of BL manga. It would have been wonderful if the mangaka had been granted enough time to reveal the characters' pasts in greater detail and follow the progress of their lives for a few more years.
The characters are interesting, and each one has a likeable, non-cliche personality. It was both moving and funny to see their defeatist attitudes towards life, and their constant denial of the reality of their situations is very believable - being something that almost anyone can relate to, at least a little. The morals behind the story are simple, but profound. And the silly "love conquers all" mantra was not flaunted here, not even once.
My favourite character by far is Nakagawa's first wife. She has an incredibly strong personality: the type you rarely see among female characters (in any demographic). I also found it quite touching that despite having left Nakagawa without hesitation, she still cares about him - though not in a romantic context. This gives her a three-dimensional quality that's quite an anomaly among women in BL. In fact, I'd have loved a few chapters focusing on her relationship with her girlfriend...but with this being a female-oriented manga, it's quite understandable why the mangaka wouldn't have wanted to take the risk.
All in all; a sweet, quick read. Despite the unrealised potential of the plot and its obviously truncated length, I'd recommend Makeinu no Nandemoya to anyone who thinks they're up for a meaningful, softcore shounen-ai with a humorous undertone.
Edit: It appears that this series actually has a sequel! Fingers crossed that it'll someday be scanlated, though there doesn't seem to be much hope of it right now.