From Fantagraphics:
This is a tale of rage. Rage against hypocrisy, injustice, exploitation, and the wrongs done to a child who grew into a righteous killer. Search and Destroy transplants the vengeful action of Dororo from feudal Japan into a dystopian future where mercenary robots known as "creatures" serve the human elite and victimize the city's scrabbling, desperate masses. The violent death of one of these creatures connects an orphaned thief named Doro with a mysterious girl in a stinking animal hide that conceals deadly cybernetic implants. Who is this mysterious girl? How is she killing, one by one, the city's most twisted and powerful creatures?

Loosely based on Osamu Tezuka's Dororo.