This was a strange one for me; I picked it up originally because I love all things "Dororo," and there is a lot for Dororo fans to like. However, the first volume is a bit of a mess--nothing's explained--and the setup is bizarre. Hyakkimaru is reborn as a teenage girl, but is still missing pieces and has an incomplete memory. Another Hyakkimaru (male) still exists; he became a demon after succumbing to hatred of the other demons in the distant past. Dororo, too, became a demon in order to save Hyakkimaru's life, and has no memory of her human self. Bon is a modern Dororo: a sneak-thief and a spy, though she needs a lot of Hyakkimaru's help.
The story has Hyakkimaru regaining a few remaining pieces and teaching Dororo how to be human again--a sort of thematic reversal of the original series. The cuts to the past were the most effective to me; seeing Dororo and Hyakkimaru separated by the quest they were once united by cuts deep. The end, too, is effective, with Dororo remembering enough of herself to spare a child from demonic wrath. Hyakkimaru's resolve to sacrifice him/herself to save Dororo is also a standout moment, and something the original series could have used.
Overall, nothing special. The art's a bit weird and the mangaka is obsessive with sound effects. If you enjoy Tezuka's Dororo, though, you might like this, too, especially if you're craving a more settled ending.
Still, if that's really what you're after, stick to Kaneko Atsushi's amazing "Search and Destroy," another Dororo remake with ten times the heart of this one and wicked cool art.