It’s summer vacation and Keiichi’s parents left him with his five younger sisters to go on an overseas trip. Now with their parents far out of the picture, his younger sisters are aggressively making their moves on him. Of course there’s no way he can hold back.

This manga is based on the second visual novel Imouto Paradise! 2. An adult manga based on the first visual novel Imouto Paradise! has already been published.

Note: The Imouto Paradise! 2 manga was designated as an "unhealthy publication" by the Tokyo Metropolitan Government, due to its "glorification of incestuous acts". It was the first publication to be formally restricted as such by the government since Bill 256 revised the law in 2010. Bookstores in Japan became prohibited from selling or renting the particular book to minors under the age of 18, and they are also not permitted to browse the book. Bookstores have been legally obligated to separate and place the book in an adult section.