Manga like the following (particularly the first two):

-Koi da no Ai da no
-Ore-sama Teacher
-Usotsuki Lily
-Gekkan Shoujo Nozaki-kun
-Skip Beat

Basically very funny, lighthearted manga with a very strong unique main character or premise. Doesn't have to be as plot heavy as Skip Beat, but not something as endlessly repetitive as The Wallflower or Special A. I also really liked the school politics in Koi da no Ai da no and Oresama Teacher, so something in that vein is welcome. Romance is not a must.

I'm pretty sure at least a few of these fit what you're looking for, check them out, they're some of my favourite manga.
Horimiya
W Juliet
Faster than a Kiss
Takane to Hana
Beauty Pop
Wotaku ni Koi wa Muzukashii
Gokusen - technically this is classified as josei and has a rather atypical art style, but don't let that put you off, it's great

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I think you would like Gals!
Also Koukou Debut
Or Juuni Hizoku no Palette

I own all of these licensed and love them.

lovely complex
[m]hot blooded girl[/m]

Both are very funny, hot blooded girl thou, if you can stand the drawing.
Lovely complex is definitely romance comedy with unique character

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My recomendations: (in order or relevence to request)
Hirunaka no Ryuusei - fantastic main characters with dynamic relationship
Namaikizakari - sports club
Orange Marmalade - if you can forgive the vampire drama
last but not least Ame Nochi Hare - (just cus I love it)

Torikagosou no Kyou mo Nemutai Juunintachi maybe