I'm looking for mangas that has a heartbreaking story where the boy/girl did not end up with each other or one of thm will eventually die. I'm also looking for the latest, from the year 2000's and so on will do. But, I'm not just only looking for a grat story, but, great art and drawings as well. Please help me!!!

P.S. I would appreciate it if you also put the link of the title and a short description why you would recommend it. Thank you very much!

Orange (TAKANO Ichigo) very much a tragedy only because the write makes you fall in love with all the characters and their interactions.

I might came back to update this. It was just the first one I thought of.

Sand chronicles
https://www.mangaupdates.com/series.html?id=215

I always cry reading this one, has some pretty heavy themes... not sure if you will be okay with the ending but, I won’t spoil it