Advertising from Kadokawa Shoten has revealed that an anime adaptation of Ran Igarashi's Hōzuki-san-chi no Aneki four-panel manga is in the works. The "abnormal sister-complex comedy" follows Gorō Hōzuki, a high school boy with an older sister named Haru who is unrelated by blood. Gorō is mortified when the self-centered and lustful Haru plays a prank on him.

Igarashi launched the manga in Young Ace magazine in 2009, and the manga now runs in 4-Koma Ace magazine. The fourth compiled volume will ship on December 13.

source: animenewsnetwork

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That's pretty awesome.

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Any updates on this adaptation 😕

Is the anime is still on the works or did they cancel it? Half a year has passed already

I think it get Cancelled, since there are no other news related to it...