Quote from Alaena Night
... I don't particularly prefer either "shoujo" or "shounen" because both usually include the same-old same-old plotline used over and over again - shoujo with the unrealistic schoolgirl romance, and shounen with the power-ups and endless fights and long, boring spiels about, "Becoming stronger to protect my friends..." and all that.
^ So much truth. But to be fair, genres don't always make or break the manga. For me, it's alll about the characters. If I like the characters enough, I can sometimes excuse the cliches being thrown around. But unfortunately, this doesn't happen often enough.
As for me, I'm female, and used to read a ton of shoujos.. but now I'm tired of most of 'em. They generally don't excite me anymore. Every now and then I do find some worth reading, but that's when it doesn't focus on romance. Nowadays it's seinen and maybe a few shounen sports I actively read.
In general though, I do try to give a story a chance if the premise seems interesting enough, whether shoujo or shounen. The only genre I mostly ignore are ecchi, harems, shoujo/shounen-ai, yuri/yaoi. Seriously, SO many shounen/seinen manga are ruined by the disgusting amount of ecchi shots thrown in there. Ugh.