This series makes wild uproar because of the apparent lack of werewolves in anime/manga. But if this as the manga depicts is what a werewolf should be like, it's a superficial and laughable creature.
I wish that I could just sum up what I think about this manga in one word seeing as readers are entranced by empty words such as "amazing", "cool", "awesome", etc. but I just couldn't bear myself to join the pack (no pun intended).
I'm sorry but this manga is a rip-off. A huge disappointment, nothing but a failed presumptuous gimmick. The average rating and the rave reviews in here are misleading. Other than the amusing beatings, slashing, kicking, slamming, and whatnot that were received by the Wolf Guy, there's little to chew on. I'm left with the characters--both protagonists and antagonists--to save me from the weak plot but they, too, are hopeless. They have little to no redeeming qualities: Wolf Guy might be mystified but smug, the female teacher is dull, and the rest of the characters are third-rate.
I know, why would I expect realism in my manga, or fiction for that matter? However, it's terribly unfair to compare this manga with Until Death Do Us Part, etc. even when the latter also has surrealism in its plot. Because as far as I know, UDDUP characters are its driving force. They have their own idiosyncrasies to look out for and to relate to whereas this manga hasn't anyone or anything for that matter.
Wolfen Crest's storyline is frivolous, which wouldn't be a problem if the characters weren't so "fake". By that I mean, there must be some paradoxes within the characters. This series' characters are so formulaic and bland that it's hard to care if any of them die of shock, ravaged by humans or ripped apart by ravenous creatures that come out of nowhere. I like both realism and supernatural in my fiction but this has neither an ounce of realism nor the excitement of supernatural. For a series about the mysticalities that are werewolves, it proves to be strangely less mysterious and more predictable as it goes on.
This series might appeal to the general or the younger masses, but it's more apt to say that it is for the "less sophisticated readers" who want a series to pass time and enjoy without having the need to digest anything. Because the only thing that will keep your attention to this manga is the artwork and fanservice. This is probably what swayed most of the readers to this inane series in the first place.
tl;dr: Waste of my time.