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Sakuranbo Syndrome  
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"Progressive Rejuvenation Syndrome." This is an extremely rare disease causing the inflicted person to gradually become younger. The main character of this story, Munenori Agawa, is the only person that could save Rena Amami from this odd disease. Agawa's saliva is the only thing that can halt the disease from making Rena younger, so they must kiss everyday in order for her to survive. This causes an immense amount of conflict and drama between Agawa and his new girlfriend, Sayako Asou. This triangle relationship story tests the capabilities and limitations of human love.


Related Series

Associated Names
さくらんぼシンドロームCherry Syndrome
Cupid No Itazura 2 Cherry Syndrome
Cupid No Itazura 2 Sakuranbo Syndrome
Cupid's Prank 2: Cherry Syndrome
Cupid's Prank II: Cherry Syndrome

Groups Scanlating
Ciel Scans
Lemon Scans
Manga Pirate

Latest Release(s)

Status in Country of Origin
11 Volumes (Complete)

Completely Scanlated?

Anime Start/End Chapter

User Reviews

4 topics, 11 posts
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User Rating
Average: 8.6 / 10.0 (304 votes)
Bayesian Average: 8.41 / 10.0
 36% (110 votes)
 24% (74 votes)
 22% (66 votes)
 10% (31 votes)
 3% (8 votes)
 1% (4 votes)
 1% (3 votes)
 0% (0 votes)
 0% (1 votes)
 2% (7 votes)

Last Updated
August 3rd 2015, 8:09pm PST



Category Recommendations





Original Publisher

Serialized In (magazine)
Young Sunday (Shogakukan)

Licensed (in English)

English Publisher

Activity Stats (vs. other series)
Weekly Pos #214 increased(+51)
Monthly Pos #265 increased(+1)
3 Month Pos #262 decreased(-49)
6 Month Pos #234 decreased(-3)

List Stats
On 2056 reading lists
On 1041 wish lists
On 112 completed lists
On 51 unfinished lists
On 370 custom lists

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Forum Posts
Ending 143 days, 10 hours, 3 minutes ago
To Whom I needs to pay to these series moved on? 1154 days, 19 hours, 11 minutes ago
why lagged behind? 1537 days, 3 hours, 2 minutes ago
Hesitant to open file 1904 days, 10 hours, 18 minutes ago

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User Comments [ Order by usefulness ]

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Rating: 10.0 / 10.0
by wallyakazukin
October 15th, 2015, 5:08pm
Aside from whether Rena's disease is a pure fiction, I like how the characters deal with it. This manga indeed contains adult materials, but they're not mind-wrecking. Instead, it's kinda encouraging, slice-of-life things. The idea is so original. The plot is solid and awesome. Rena who can't live without Agawa's kiss, even though they don't love each other. And Asou, Agawa's girlfriend who has to deal with Rena. How Asou-Agawa's love development despite Rena's problem. How Rena deal with her family and her dream-boy (which is, thank god, not Agawa) about her disease.Everything's wrapped beautifully.
Asou is a great woman, and she's my favorite character here smile
Anyway, if you're 18+, fine with some nudity, and tired of stupid smut or shallow shoujo ordinary plot, I highly recommend this manga. Super interesting.
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Great characters.   
Rating: 9.0 / 10.0
by melquiades
September 4th, 2015, 12:32am
Would it be bad if I loved this series so much because of the MC's girlfriend? I just love her character.

Don't get me wrong here, the series is rock solid on its own, but i think i wouldn't be so enthralled with this series, if she were depicted any other way.
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Best since "Strawberry 100%"   
Rating: N/A
by cecropiamoth
February 25th, 2013, 10:50am
Both manga have the terrific quality of showing us highly believable, somewhat idealized relationships. Of course the semi-lolicon subplot in this one is absurd, but the depth of understanding of the amazing messes that people can get into when they're trying to work out a relationship is as spot on here as it was in "Strawberry". The only difference is that "Strawberry" had younger characters

As for the semi-loli subtext, well, having it in there is just another example of the unique genius of manga, IMHO. Having read literally thousands of manga, I've come to realize that having an element in the story that's JUST over the line of standard morality is the genius of this form.

Cartoons with titillation. It's a brilliant combination! The use of cartoons is a great advantage for the storyteller because it make it possible for him to present impossibly beautiful people and impossible adventures. The addition of slightly transgressive titillation elements in turn makes up for the one great drawback of cartoons -- there can't be enough text/conversation in them to fully convey the characters' feelings and thoughts and by doing so hold the interest of a smart and/or adult reader.

This is one of the best manga I've ever read. As far as I'm concerned it shows how amazingly much truth about human feelings a cartoon medium can convey.

... Last updated on February 25th, 2013, 1:01pm
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Rating: 8.5 / 10.0
by lamansonbleue
September 2nd, 2012, 4:13am
at first the plot seemed ridiculous but it was surprisingly good...
I want to see how this end... Rena x Amagi seems pretty "obvious" so I hope that's not going to happen.
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every man's dream, sorta   
Rating: N/A
by pxhai
May 30th, 2012, 2:04pm
kudos to the manga-ka. Some serious shits here to get away from the overwhelming amount of wimpy romantic shounen. Quite a strange way to form an awkward triangle. And horny situations bigrazz. Really curious about the ending, as I read the raws but didn't comprehend what happens at the end.
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Very Interesting   
Rating: N/A
by jeffreymgibson
April 4th, 2012, 9:06pm
I've read through Volume 4 and it's pretty interesting. You do have to suspend your belief big time in order to buy the plot though. If this were a real life story, something like this would be terrible. I feel for the girlfriend, she has the shortest end of the stick. She's the one who is probably suffering the most and the boyfriend doesn't do much to try to comfort her or make her feel better. However, he never wastes a single seconds in running to Rena's side when she needs a hand. He's really a little low down.
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Rating: 8.0 / 10.0
by Verix
March 4th, 2012, 10:58am
Like usual with Kitazaki Taku's works, it's pretty twisted, but the kind of twisted I can appreciate. If you don't get too absorbed and don't take it too serious, it's a pretty addicting and fun read. Recommended.
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This is a story about how scary women are ^^;   
Rating: 9.0 / 10.0
by fictionalscience
January 15th, 2012, 7:08pm
As some others have said, this is one little messed up series XD Should be tagged as "psychological" as well. Not too easy to just read through, sometimes the drama, jealousies, twisted stuff, etc are scary as hell. But very interesting! It's definitely quite a different kind of manga, totally worth reading smile

Oh and also, 100 points to the mangaka for making the main character a hot guy \(*o*)/

... Last updated on January 15th, 2012, 10:05pm
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Somehow this is more like the dream of men and harsh reality for women   
Rating: N/A
by sosise
September 23rd, 2011, 12:30am
The story, although initially based on the disease, actually focusing on live style and relationship. Triangle loves are fine, but in this manga, somehow I feel that the main man character is just so despicable. The only thing I get from this manga is that essentially the mangaka potrayed that all women are stupid and only capable to love one love in her whole life. I bet in real life, no women would want to accept the shit of watching her own boyfriend kissing another girl.

Story wise, I feel like vomit because the mangaka is trying to portray that the small girl is very pitiful. In reality, she could do something else, like using lab-assisted saliva preserving. (I admit I only read vol 4 and 5, but I believe that saliva can be transferred on different ways other than kissing each other).
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Rating: 10.0 / 10.0
by jasperv
September 6th, 2011, 2:47am
it's rare to have some mature(in real matue not teenage) romance in manga to be serious a nice change from overage series flooding the scene
I hope more translators keep these unknown gems
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