Great Teacher Onizuka had a ton of those moments for me.
So did BECK, and Hajime no Ippo. all those made me cry, at points. 😀

Can't read >_<

Er.. Nana? Depressing really but not really the best sad moments.. i call it one of the sad moments that jump into your mind.

R-18 below
[img]https://dl.dropboxusercontent.com/u/32718267/aot.jpg[/img]
Detective Horror Series

Tracker BakaBT

I agree with UberZombie, GTO had some really sad moments, though you laugh like hell most of the time. FMA in general is pretty sad, for both the anime and the manga. Personally, Gantz has plenty of moments where I just shouted "noooooo, why did (character's name here) have to die?!?!"

"When we remember we are all mad, the mysteries disappear and life stands explained."

• Samuel Clemens/Mark Twain

Quote from newbie56k

Ai Ren will definitely make you cry.... cause i cried every time i read it T^T... (and thats 10 times). Its a very good story.. The sadness is like a good sadness, its not like a feeling that you lost something, but its a sadness that they accomplished something impossible, and you miss them soo much~~ all the happy and fun times..
gahh~~~ .... im starting to cry T^T~~!!!!

My Lovely Ghost Kana is also a good read, but I believ

i cant even think of ai-ren without getting tears in my eyes.
this was truly the best sadness ive ever felt in my LIFE!
if you think im overreacting, read it. youll cry for sure.

Quote from Cradial

i cant even think of ai-ren without getting tears in my eyes.
this was truly the best sadness ive ever felt in my LIFE!
if you think im overreacting, read it. youll cry for sure.

I was so sad reading it, it is one of, if not the, the most upsetting piece of fiction I have ever read 😢

I've got to burn your eyes.

Quote from Eiskaltnz

Quote from Cradial

i cant even think of ai-ren without getting tears in my eyes.
this was truly the best sadness ive ever felt in my LIFE!
if you think im overreacting, read it. youll cry for sure.

I was so sad reading it, it is one of, if not the, the most upsetting piece of fiction I have ever read 😢

yup and thats why i will not read it

http://narutofever.com/naruto-characters/pictures/anko-sig.gif
[img]http://i9.tinypic.com/4p4umpw.gif[/img]
[img]http://img85.imageshack.us/img85/4538/sigmagumvy9.jpg[/img]
we are all of the creed
the creed we worship rules us all
the creed of okutoness forever
that and when the next flight to japan

Personally, if I know the manga is sad, I wouldn't feel sad when it happens since it's expected. From what I remember not a single manga has ever made me cry. But anyway, back to topic, I would suggest Mucha Kucha Daisuki.

Bitter Virgin
Elfen Lied

Glados is a bitch. She made me kill the companion cube, the only friend I'll ever have. 😢

Chibidoro-sama=Neko-freak

Quote from vinceasuma

I cry a little bit after every chapter of Naruto....

sob it used to be good sob

lol nicely put

Well, Berserk is sad in some places, I guess? It's the best I can come up with, at least. Also, FMA has some powerful moments. Oh how I love that manga~

"The light shines in the darkness, and the darkness has not overcome it."

Hotman (seinen)
One Piece (shounen)
Video Girl Ai (seinen?)
Cat Street (shoujo)
Vampire Juuji Kai (tragedy)
Battle Angel Alita (seinen)
These are all good manga series with sad moments. Oh, and there's a oneshot called Forever Honey that is very touching.
I know you want manga, but there is an animated movie called Grave of the Fireflies. I personally think it's a tear-jerker since my sister was crying buckets at the end.

Yu Yu Hakusho

Glados is a bitch. She made me kill the companion cube, the only friend I'll ever have. 😢

Chibidoro-sama=Neko-freak

NHK ni Youkoso! got me more than a few times. Seinen to the bone, and genius to the core; sometimes hilarious and other times ungodly depressing, and even frightening (and not the, "ZOMG MONSTAAAZ" type of fear--the "Is this what we all come down to? When there's nothing else does this happen? How close to the brink am I?" type of fear). If you read this without getting depressed, you're a chump. Hell, I cried a few times.

I am the God of Freedom. I am not revered, I have no shrines; and you have never before heard of me nor will you ever hear of me again.

The ending of the Eureka Seven manga was really sad.

Bitter Virgin is definetly sad. Butr it is really good anyway.

towards the end of mars was really sad... and deep love series are tear jerkers.. definitely! T_T