I'm looking for a manga that has a female character( doesn't have to be the lead) that has superhuman physical strength. Examples would be Claymore, Medaka Box, and Hoshi no Samidare.

Manga is never short of these, especially with comedy.

Anime wise: Project A-ko. An iconic anime to many.
Also Samurai Pizza Cats. Trust me, it's good.

Rumiko Takehashi has these in : URUSEI YATSURA & RANMA1/2

Jin Kobayashi School Rumble

Black God

Tenchi Muyo

One particular girl (no prizes for guessing who, sorry) Fruits Basket

Junk Force

Battle Angel Alita
Shin Angyo Onshi
Fate/Stay Night
Elfenlied
To Aru Majutsu no Index

Ummm... Shiawase Kissa Sanchoume? *giggles. Though, it's a Shoujo, slow romance, comedy...

karakuri odette -but she is a robot.
ryuu no hanawazurai - she can change into dragon
gokusen - not superhuman strength but she is really stronger than man
superior - she is demon queen, so no wonder she is really strong.
yankee-kun to megane-chan

Air Gear-many, one I'm thinking of is a wrester
Defense Devil-magic enhanced
Hellsing-vampire girl
Noblesse-another vampire
Tales of Symphonia-modified by magic crystal
Vampire Juujikai-half vampire

Im thinking maybe Oresama Teacher maybe? She's straonger than everyoneelse but it's not superhuman...thats all I can think of right now...

onihime vs
freezing

Murder Princess
To Aru Kagaku no Choudenjibou
Love Hina

That's all I could think of that would fit your request perfectly 🙂

“I thought also of another thing between us. Call it trust... That is one of its names. It is a very great thing. Though each of us alone is weak, having that we are strong, stronger than the powers of the dark.”

Choegang Geunyeo

Onidere

Good ol' Dr. Slump by Akira Toriyama (of Dragonball fame). Arale defined most of the trope IMHO. And the comedy is great.

Gokusen - Have you read/watched Great Teacher Onizuka? Replace him with a she and there you have it. There are some differences, there's no ecchi for example.

Old thread, but what the hey... 😎

Sumomomo Momomo

There's also an anime, but of course the manga goes much farther.