I don't often see manga with this kind of theme taken even remotely seriously, which is why I'm very glad I came accross this. It deals with serious issues and there's enough romance to satisfy the typical josei/shoujo readers, without depicting the romance as abhorrently cliche.The struggles the characters go through, while slightly overdramatic, are realistic and not limited to the people with intersex characteristics. Both the main characters deal, in their own way, with a society that looks fown on people who don't fit into the neat box of 'male' and 'female'. The secondary characters are well thought out and go through their own struggles.
I only have a few gripes with this manga, which I'm going to agree somewhat with KoariNite. The issue of surgery for people of intersex, I'm sure, has to be far more complicated than that. From what the mangaka seems to be implying, for a person to have gender assignment surgery would leave their personality irrevocably altered into the mindset of the 'gender' they decide to become. It seemed to be especially implied in the case of Haru. Now, I'm not denying that there are differences between sex. Still, at least for most people, I'm in serious doubt that an individual who has been wearing shorts and t-shirt their whole life, and are into sports, are going to suddenly have a total 180 in personality, and suddenly decide they like make-up, fashion and dresses instead.
There's only this little issue though, and may only be me who sees it that way. Overall, I'd say defiantely read it, you don't often see the issue of intersex taken very seriously in manga.