Mid-Edo period. Kuzuryu, a swordsman who is also a drug dealer and hitman, pursues the mystery hidden of Kuzuryu in order to uncover the truth about his birth and the death of his family.

Agent Leon Kennedy is on a mission to rescue Dr. Antonio Taylor, but a mysterious woman gets in the way. Meanwhile, Agent Chris Redfield investigates a zombie outbreak in San Francisco, where the cause of th...