It's impossible to just pick one 😀

My favorites are (sorry for any misspellings, I'm horrible with names)

Sano x Mizuki - Hana Kimi
Makino x Domyoji - Hana Yori Dango
Sara x Soujiro - Hana Yori Dango (Even if it was a side story, it was one of the most memorable parts of the manga for me...If only it worked out 😢 )
Yoh x Haruna - Koukou Debut
Sawako x Kazehaya - Kimi ni Todoke
Ren x Kyoko - Skip Beat
Chae-gyung x Shin - Goong
Sumi x Souchiro - Hadashi de Bara wo Fume
Soah x Haebaek - Bride of the Water God

Yes I know, these are from the more mainstream mangas, and sure there were other couples that I liked, but none of them really stuck with me except for these 🙂

[img]http://i28.tinypic.com/2rbze4g.png[/img]

Although for some reasons I feel most shoujo couples are superficial and have less chemistry then most shounen couples,

i'd have to say the best 3 couples (purely chemistry wise)are

1. OtanixKoizumi in Lovely Complex
2. HarunaxYoh in Koukou Debut
   3 and tied for third are...
   YuikoxLeo from Beast Master
   or HarunaxMacharu Saruyama

[img]http://farm3.static.flickr.com/2777/4207527145_31aa2e1471_m.jpg[/img]

kyohei and sunako (Perfect Girl Evolution)
sakura and shaoran (Cardcaptor Sakura)
sana and hayama (Kodomo no Omocha)
shinichi and ran (Detective Conan)

The river of life is magnificent and dangerous.

i feel same.. i cannot only answer one couple. so i'll tell ya.. some

Kyoko Mogami X Ren tsuruga (Skip Beat)
Ryu X Taiga (Toradora)
Mikan X Natsume (Gakuen Alice)

Etc ^0^ (it'll be increase since the manga produce every time)

Kazehaya X Sawako (Kimi ni Todoke) 😀
Kurosaki X Teru (Dengeki Daisy)
Zero X Yuuki (Vampire Knight)
Ren X Kyouko (Skip Beat!)
Usui X Misaki (Kaichou wa Maid-sama!!)
Ikuto X Amu (Shugo Chara)
Kanade X Saku (Hoshi wa Utau)

Quote from juliyanti

Ryu X Taiga (Toradora)

Toradora is shoujo? >.>

Kira and Rei from Mars
The Otomen couple
Beast Master,
and Kimi ni Todoke

Not officially a couple (yet), but still surprised they haven't shown up on this thread yet:

Zen/Shirayuki (Akagami no Shirayukihime) has some of the most solid development I've read in a long time.

Quote from story645

Not officially a couple (yet), but still surprised they haven't shown up on this thread yet:

Zen/Shirayuki (Akagami no Shirayukihime) has some of the most solid development I've read in a long time.

Agreed. One of my fave shoujo couples.

I also enjoy Kurosaki/Teru from Dengeki Daisy and Ryuu/Chizuru from Kimi ni Todoke. Hm, I'll throw in Vivi/Hana from Hana to Akuma for pure feel-good fluff. 😀

i like Zen/Shirayuki from Akagami no Shirayuki hime
Zero/Yuuki from Vampire Knight
Len/Kahoko from La Corda D'oro
Chihiro/Sakuya from Hoshi Wa Utau
Natsume/Mikan from Gakuen Alice 😃

I have to agree with Yenoh. Mars, Rei and Kira, my personal favorite.
Hana Kimi - Sano and Mizuki
Immortal Rain - Rain and Machika
Fushigi Yuugi - Tamahome and Miaka
Chobits - Chi and Hideki
Angel Sanctuary - Sara and Setsuna
Marmalade Boy - Yuu and Miki
Kimi wa Pet - Sumire Iwaya and Momo
The Demon Ororon - Chiaki and Ororon

Well...

Sakura x Syaoran from CCS and Tsubasa
Usagi x Mamoru from Sailor Moon
Zero x Yuuki from Vampire Knight

I'll hug your problems away.

Yoh x Haruna from Koukou Debut.
I really like that couple <3

Hatori x Mayuko from Furuba.
Sakura x Sayoran from Card Captor Sakura.
Mizuki x Kazura from Platinum Garden.
Candy x Albert from Candy Candy.
Kohaku x Shuichiro from Wish.

Jae x Michael from Model.
Asarella x The Demon Lord from Masca.
(those are both Josei though)

Usually the pairings I like
are notorious for not actually happening. 😢

SyaoranxSakura=Sweet

KazehayaxSawako=Adorable

KyouxTohru=Beautiful

[img]http://i32.photobucket.com/albums/d25/khmershinobi/b750d351697e8dd4b2600bce2a15e1e9-2-2.jpg[/img]

__ I'll have what she's having... please~♥

Quote from khmershinobi

KazehayaxSawako=Adorable

What story is that? I'm not familiar with the names.

If you've ever thought or said "Nice Guys finish last" and really meant it, then you should probably read this LJ post by DivaLion. It's incredibly insightful whether you're male or female.

From a bumper sticker I like:
"If you're gonna ride my ass, at least pull my hair."