Manga where a female protagonist has something wrong with her, but love interest dosen't care. Like a large scar, or other preferably physical impairment. She spends a while (not revealed in one chapter) trying to keep it hidden. When is finally does come out, the lover interest doesn't care. Can be yuri, but not yaoi.

Or we could subvert it and have the lover interest care and think its disgusting/distasteful, that would be cool too.

Limited Lovers
After School Nightmare
Mars (though it's mental, not physical)

Hmm Bitter Virgin kinda fits.

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Yes, I read bitter virgin and really liked it.

Cyboy
Deep Love - Ayu no Monogatari: Also read the sequel, Deep Love - Host.
Kemono wa Hana no Yume wo Miru ka

Last edited by xgloriOHz at 12:26 am, Jul 7 2010

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Does being a vampire count as something wrong? If so, then Karin.

You might also be interested in Kingyo sou. It has a female protagonist, except the romantic interest "has something wrong" with him.

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Feed your head.

I second Kingyo Sou.

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Having a good time...

Sundome

Yeah, this probably isn't your cup of tea.

But it fits the description.

Hana wa Knife o Mi ni Matou, kind of?

Although this isn't really a shining example of a great manga...