Hey-yo!

Anyone familiar with the song 'Lonesome Loser'?
If so, you already know what this next search is about.

But I'll say it anyway.
Manga I'm interested in now revolves around the uphill-downhill struggle of those who had or going to hit rock bottom. They come in many names:

Losers, Talentless wannabes & has-beens, you know those underdogs in the shadow of society.

Poverty,Delinquints,etc don't count.

Genre can be anything from comedy (my personal favourite) or serious.

Any character role is acceptable: Minor, Sub or Main. As long as they can fit under loser or talentless.

Good luck folks.

Hanazawa Kengo does good loser manga. I would mostly recommend Boys on the Run for your request. But since there's not a lot of that translated, you're probably better off with Ressentiment, at least for now.

Other than that, one of my favourite loser manga is Ore wa Mada Honki Dashitenai Dake. (It's a also a bit funnier than Hanazawa's stuff.)
Or for more slapstick comedy about losers, maybe Boku to Issho.

Saikyou Densetsu Kurosawa might be the exact thing you are looking for.
Tobaku Mokushiroku Kaiji is really good too.
All of Fukomoto Nobuyuki's works feature many characters like this.