I'm looking for titles that involve a sacrifice by the male protagonist to save the world, protect those important to him, etc.

I'm fine with the character either being dead or alive (from being revived), and I would prefer if romance was part of the genre with the demographic being shounen or seinen.

Examples: Busou Renkin, Zero no Tsukaima: Futatsuki no Kishi, Heroic Age

I accept both anime and manga series.

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Vampire Juujikai
I doubt it will disappoint.

If you don't mind a game

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Is this me in a nutshell?
Pretty much.

Sexual Hunter Riot

He sacrificed his ability to get an erection.

/troll

Is live action OK? I just saw the live action film remake of the old series Space Battleship Yamato, and it is exactly like that.

Code Geass is the king in this category
Tengen Toppa Gurren Lagann is good too

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