Quote from UMMX
Yes Akatsuki leader was Uchiha Madara in the past. But the new Leader face has not been show. It could be the 4th but i think it someone else in Naruto blood line.
Also so far the manga keeps on saying that Uchiha Madara and the Hokage started around the same-time. So i think that Naruto blood line is in both houses...
Unfortunately since I read ch 372, I doubt that Naruto has any specific blood connection to anyone who is still alive whether heroes or villains. Ch 372 dashed any hopes I had toward that conclusion other than Kishimoto-sensei draws very similar faces for many characters. I don't think Uchiha Madara is related to Naruto only to Sasuke as an Uchiha, also I don't think that 4th Hokage came from any sort of old blood - family (aka Uchiha's, Hyoga's or any bloodline limit familys), all was told he was a singular genius and I assume he came from normal ninja family or from just any normal resident family of the hidden leaf village. If Naruto came from any sort of noble bloodline from hidden leaf village families', I am certain he would be living with that clan now, he might have been despised and feared for being 9-tail fox but he wouldn't have been living alone in a small apartment like he does now.
The only way Naruto is related to any substantial family or bloodline would be thru his mother's Uzumaki family which hails from now extinct Land of the Whirlpool. Furthermore, Akatsuki major players - those former kids from Amegakure are not related in any way to Naruto too.
For this arc, I doubt we will find out anything signifacant relating to Naruto family or bloodline.
Also, Kishimoto-sensei described Naruto many times as being alone, no family no nothing from beginning and then gaining friends who become his family, I think at this point finding Naruto any blood connection other than being related to 4th hokage, would be pointless to do and defeat the whole point of him being family-less and alone.