If I'm not mistaken; the new manga, Code: Breaker has a female lead.

And the manga kicks ass too.

Dogs, Variante, Black Lagoon, Claymore, NOise, and Code: Breaker.

A new find: Megalomania.

InuYasha has both a female lead, and a male lead, so to speak.

There is Tenjou Tenge, although it is kind of a stretch because (1) it is seinen, not a shounen, series, and (2) there are a couple of principle characters and one of them is a guy. Nevertheless, I'd say that Natsume Maya is basically the main character next to Souichirou (her love interest), and her sister Aya plays a pretty important role as well. I know it isn't technically a shounen series, but I couldn't help mentioning it anyway. Especially since I like Maya so much, and I think its hard to find shounen/seinen manga with female leads that are likable (for me, a girl, anyway).

Oh, and I just remembered Yozakura Quartet. It has three female leads (and one not very strong male lead). 🙂

Some I know are:

-Aqua[preque]
-Aria[sequel]
-Deadman Wonderland; Shiro[female lead] becomes more important than Ganta[male lead] as the plot developes.
-Superior
-Fullmetal Panic
-Matsuri Special; shoujo-ish..

-Read or Die is seinen but it's good...and who doesn't like sexy librarians? XD

"Beware How You Take Hope From Another Man."

I can't believe no one has mentioned this:
Air Master.
It is seinen but it has a female lead that kicks ass. Not many chapters of the manga are out but the anime is complete and its awesome.

Good Grief.. no one has ever mentioned this - Zero no Tsukaima
the lead was a female. have anyone ever read this? it's surprisingly good. if you want a full story, try reading the novel.

Ras tel ma scir magister Veniant Spiritus Aeriales Fulgurientes!! Cum Fulguratione Flet Tempestas Austrina, Jovis Tempestas Fulguriens!!!

Eternal Sabbath
Fairy Tail
Hataraki Man
Jisatsu Circle
Koe de Oshigoto
Sakuran

Avatar by tassyn.livejournal.com

Reading: Kingdom, Sangokushi, Historie

Ice Revolution is hilariousss. But it gives off a shojo feel even though it's categorized as shounen....

Forever lurking...

Quote from Wererat42

Quote from hyery

• Kurohime
• Shakugan no Shana
• Omamori Himari

Good finds, but actually these go under a category I call "FFXII Syndrome". Even though the story may be about the girl, or she might be a stronger and more developed character than him you still have to have a central male lead opposite the female lead so that you don't alienate your male readers who have a hard time relating to a female protagonist.

Not the case with Kurohime.

Also: Kurokami
Battle Club
Seikon no Qwaser

Listen here
Livin just to keep from dyin
[img]http://imagegen.last.fm/TheDarkTen/recenttracks/imgooley.gif[/img]

Wow... my thread still lives!
A few more additions... regularity of scanlation release varies.

Bamboo Blade B
Bara no Maria
Deus x Machina
Go! Tenba Cheerleaders
Junketsu no Maria
Mondlicht - Tsuki no Tsubasa